Itraconazole

Category: pharmacological

Aliases: Sporanox

Pharmacological Mechanism

Triazole antifungal — fungal CYP51 inhibitor. Strong CYP3A4 inhibitor + P-glycoprotein inhibitor — major DDI perpetrator (statin myopathy, ergot crisis, sedative oversedation). Highly lipophilic; absorption requires gastric acid + food (capsule) but solution form is enhanced.

Half-Life (t½)

PO: 21h, IV: 21h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 400 mg)

Target Organ Systems

• nervous
• cardiovascular
• digestive
• immune-hematologic

Interactions

• Simvastatin
• Cyclosporine
• Midazolam
• Triazolam
• Alprazolam
• Atorvastatin
• Lovastatin
• Oxycodone