Alprazolam

Category: pharmacological

Aliases: Xanax

Pharmacological Mechanism

Benzodiazepine — positive allosteric modulator of GABA-A at the α1/α2/α3/α5-BZ site. Triazole ring confers short t½ + high potency. Greater anti-panic activity than diazepam.

Half-Life (t½)

PO: 16h, SL: 16h

Dosing Guidelines

• PO: Typical 1.5mg (Range: 0.25 - 4 mg)
• SL: Typical 1.5mg (Range: 0.25 - 4 mg)

Target Organ Systems

• nervous

Interactions

• Opioids