Midazolam

Category: pharmacological

Aliases: Versed

Pharmacological Mechanism

Short-acting benzodiazepine — GABA-A α1/α2/α3/α5 positive allosteric modulator. Procedural sedation, anxiolysis, anterograde amnesia. CYP3A4 substrate — major DDI source (azoles, macrolides, ritonavir massively prolong sedation). Reversible with flumazenil.

Half-Life (t½)

IV: 2.5h, PO: 2.3h, IN: 2.3h

Dosing Guidelines

• IV: Typical 2mg (Range: 1 - 5 mg)

Target Organ Systems

• nervous
• digestive