Midazolam

Category: pharmacological

Aliases: Versed

Pharmacological Mechanism

Short-acting benzodiazepine — GABA-A α1/α2/α3/α5 positive allosteric modulator. Procedural sedation, anxiolysis, anterograde amnesia. CYP3A4 substrate — major DDI source (azoles, macrolides, ritonavir massively prolong sedation). Reversible with flumazenil.

Half-Life (t½)

IV: 2.5h, PO: 2.3h, IN: 2.3h

Dosing Guidelines

• IV: Typical 2 mg (Range: 1–5 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• GABA-A receptor signaling (activator) — BZD site (α1/2/3/5)

Chemical Identifiers

• PubChem CID: 4192
• Formula: C18H13ClFN3
• Molecular weight: 325.77 g/mol
• InChIKey: DDLIGBOFAVUZHB-UHFFFAOYSA-N
• SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F

References

• PMID 6138080
• PMID 27780297