Cyclosporine

Category: pharmacological

Aliases: Cyclosporin A, Sandimmune, Neoral

Pharmacological Mechanism

Binds cyclophilin → inhibits calcineurin → blocks NFAT dephosphorylation → prevents T-cell IL-2 transcription. CYP3A4 + P-gp substrate — massive interaction list. Narrow therapeutic index; therapeutic drug monitoring mandatory.

Half-Life (t½)

PO: 8h, IV: 8h

Dosing Guidelines

• PO: Typical 6.67mg (Range: 5 - 10 mg)
• IV: Typical 6.67mg (Range: 5 - 10 mg)

Target Organ Systems

• digestive
• immune-hematologic

Interactions

• St. John's Wort
• Colchicine
• Berberine
• Rosuvastatin
• Atorvastatin