Rosuvastatin

Category: pharmacological

Aliases: Crestor

Pharmacological Mechanism

Same HMG-CoA-R inhibition mechanism; hydrophilic (low CNS penetration → theoretically fewer cognitive side effects). Primarily renal + minor CYP2C9 metabolism — fewer CYP interactions than atorvastatin / simvastatin. Most potent statin by mg — 5 mg ≈ atorvastatin 10 mg.

Half-Life (t½)

PO: 19h

Dosing Guidelines

• PO: Typical 16.7mg (Range: 5 - 40 mg)

Target Organ Systems

• cardiovascular
• digestive
• renal