Category: alkaloid
Aliases: Colcrys, Mitigare
Binds β-tubulin at the vinca-site → blocks microtubule polymerisation → inhibits neutrophil chemotaxis, NLRP3 inflammasome assembly, and intracellular trafficking. Low-dose indication in stable CAD (LoDoCo2 trial 2020) — reduces recurrent MI via inflammasome suppression. Narrow therapeutic index — CYP3A4 and P-gp inhibitors drastically raise exposure and toxicity.
PO: 31h