Piperine

Category: alkaloid

Aliases: BioPerine, Black pepper extract

Pharmacological Mechanism

CYP3A4 and P-glycoprotein inhibitor (also inhibits UGT glucuronidation). Dramatically increases systemic exposure of co-administered CYP3A4 substrates — famously raises curcumin AUC ~20-fold. Also enhances intestinal epithelial absorption by increasing membrane permeability. The same mechanisms create real drug-interaction risk with narrow-therapeutic-index CYP3A4 substrates.

Half-Life (t½)

PO: 2.5h

Dosing Guidelines

• PO: Typical 10mg (Range: 5 - 20 mg)

Target Organ Systems

• digestive

Interactions

• Quercetin
• Colchicine
• Curcumin