Flavonol aglycone with mast-cell-stabilising activity (inhibits PLA2 + histamine release), nlrp3 inflammasome inflammasome suppression, and zinc-ionophore activity (shuttles Zn²⁺ across cell membranes, repurposed in early COVID protocols). CD38 inhibitor — preserves cellular nad plus (see niacin nad synthesis) by slowing its CD38-driven hydrolysis. Poorly bioavailable as aglycone; glucoside forms (rutin, isoquercitrin) have better absorption.
Half-Life (t½)
PO: 11h
Dosing Guidelines
PO: Typical 667 mg (Range: 500–1000 mg)
Target Organ Systems
immune-hematologic
Interactions
Zinc (synergistic): Ionophore mechanism — intracellular Zn²⁺ rises with co-administration.
Piperine (synergistic): Piperine increases quercetin F; standard bioavailability-enhancer pairing.
Fisetin (synergistic): Both flavonols with overlapping senolytic and CD38-inhibitory activity.
Rutin (synergistic): Rutin is the rhamnoglucoside prodrug of quercetin. Quercetin aglycone has higher and faster plasma exposure; rutin is slower-release via microbial deglycosylation.