Lovastatin

Category: pharmacological

Aliases: Mevacor, Altoprev

Pharmacological Mechanism

First FDA-approved statin (1987). Lactone prodrug from Aspergillus terreus. CYP3A4 substrate — interaction-prone. Lower-potency than newer statins — largely displaced clinically.

Half-Life (t½)

PO: 3h

Dosing Guidelines

• PO: Typical 33.3mg (Range: 10 - 80 mg)

Target Organ Systems

• cardiovascular
• digestive