Triazolam

Category: pharmacological

Aliases: Halcion

Pharmacological Mechanism

Short-acting triazolobenzodiazepine — positive allosteric modulator at GABA-A BZD site (α1-preferring). Used for short-term insomnia and procedural sedation. Extensively metabolized by CYP3A4 — sensitive to CYP3A inhibitors (azoles, ritonavir, clarithromycin) which can extend the t½ markedly. Rapid onset, short duration.

Half-Life (t½)

PO: 2.6h

Dosing Guidelines

• PO: Typical 0.25mg (Range: 0.125 - 0.5 mg)

Target Organ Systems

• nervous