Oxycodone

Category: pharmacological

Aliases: OxyContin, Percocet (+APAP), Roxicodone

Pharmacological Mechanism

µ-opioid receptor agonist with some κ-opioid activity. Unlike hydrocodone, oxycodone itself is active (doesn't require CYP2D6 conversion). Oxymorphone is an active metabolite.

Half-Life (t½)

PO: 3.5h, IV: 3.5h

Dosing Guidelines

• PO: Typical 13.3mg (Range: 5 - 30 mg)
• IV: Typical 13.3mg (Range: 5 - 30 mg)

Target Organ Systems

• nervous