Fluconazole

Category: pharmacological

Aliases: Diflucan

Pharmacological Mechanism

Triazole antifungal — inhibits Candida / Cryptococcus 14α-demethylase (CYP51) blocking ergosterol synthesis. In humans inhibits CYP2C9, CYP2C19, and CYP3A4 — moderate DDI perpetrator at doses ≥ 200 mg/d (warfarin INR rises predictably). Renally cleared; long t½ allows once-daily dosing.

Half-Life (t½)

PO: 34h, IV: 34h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 400 mg)

Target Organ Systems

• digestive
• immune-hematologic

Interactions

• Warfarin
• Tacrolimus
• Cyclosporine
• Phenytoin
• Losartan
• Ibuprofen
• Celecoxib
• Fluvastatin
• Omeprazole
• Diazepam
• Midazolam
• Triazolam
• Glimepiride