Irreversible H+/K+-ATPase inhibitor — covalently binds activated proton pumps in gastric parietal cells. CYP2C19 substrate (poor metabolizers have 5× higher AUC); also moderate CYP2C19 inhibitor (lowers clopidogrel activation).
Half-Life (t½)
PO: 0.6h, IV: 0.6h
Dosing Guidelines
PO: Typical 20 mg (Range: 20–40 mg)
Target Organ Systems
digestive
Interactions
Clopidogrel (caution): CYP2C19 inhibition reduces clopidogrel ACTIVATION (clopidogrel is a prodrug). Angiolillo 2011 (PMID:20844485): omeprazole reduced clopidogrel active-metabolite AUC by 40-47%; pantoprazole only 14% (preferred PPI when clopidogrel is needed). Solver model assumes perpetrator → reduces victim clearance, so this prodrug-activation pattern doesn't fit kinetics block; effect captured in note only.