Omeprazole

Category: pharmacological

Aliases: Prilosec

Pharmacological Mechanism

Irreversible H+/K+-ATPase inhibitor — covalently binds activated proton pumps in gastric parietal cells. CYP2C19 substrate (poor metabolizers have 5× higher AUC); also moderate CYP2C19 inhibitor (lowers clopidogrel activation).

Half-Life (t½)

PO: 0.6h, IV: 0.6h

Dosing Guidelines

• PO: Typical 20mg (Range: 20 - 40 mg)

Target Organ Systems

• digestive

Interactions

• Clopidogrel