Category: pharmacological
Aliases: Plavix
Thienopyridine antiplatelet prodrug — CYP2C19-mediated activation to thiol metabolite that irreversibly blocks platelet P2Y12 ADP receptor. CYP2C19 poor metabolizers + PPI co-administration reduce activation, lowering antiplatelet effect (clinically meaningful with omeprazole/esomeprazole; less with pantoprazole).
PO: 6h