Glimepiride

Category: pharmacological

Aliases: Amaryl

Pharmacological Mechanism

Third-generation sulfonylurea — same K-ATP β-cell mechanism but lower hypoglycemia rate than glyburide. CYP2C9 substrate. Once-daily dosing.

Half-Life (t½)

PO: 8.2h

Dosing Guidelines

• PO: Typical 4 mg (Range: 1–8 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• Insulin signaling + glucose homeostasis (activator) — KATP channel block (SUR1)

Chemical Identifiers

• PubChem CID: 3476
• Formula: C24H34N4O5S
• Molecular weight: 490.62 g/mol
• InChIKey: WIGIZIANZCJQQY-UHFFFAOYSA-N
• SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C

References

• PMID 20110017