Glimepiride

Category: pharmacological

Aliases: Amaryl

Pharmacological Mechanism

Third-generation sulfonylurea — same K-ATP β-cell mechanism but lower hypoglycemia rate than glyburide. CYP2C9 substrate. Once-daily dosing.

Half-Life (t½)

PO: 8.2h

Dosing Guidelines

• PO: Typical 4mg (Range: 1 - 8 mg)

Target Organ Systems

• digestive