Celecoxib

Category: pharmacological

Aliases: Celebrex

Pharmacological Mechanism

Selective COX-2 inhibitor → preserves GI-protective COX-1 prostaglandins → reduced GI bleeding vs non-selective NSAIDs. Tradeoff: selective COX-2 inhibition shifts the PGI2/TxA2 balance toward thrombosis — CV risk concern (rofecoxib/Vioxx withdrawn 2004; celecoxib survived PRECISION trial). Sulfonamide — caution in sulfa allergy.

Half-Life (t½)

PO: 7.8h

Dosing Guidelines

• PO: Typical 133 mg (Range: 100–200 mg)

Target Organ Systems

• cardiovascular
• immune-hematologic

Pathways It Modulates

• Arachidonic acid cascade (inhibitor) — COX-2 selective

Chemical Identifiers

• PubChem CID: 2662
• Formula: C17H14F3N3O2S
• Molecular weight: 381.37 g/mol
• InChIKey: RZEKVGVHFLEQIL-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

References

• PMID 10749518