Diazepam

Category: pharmacological

Aliases: Valium

Pharmacological Mechanism

Prototype benzodiazepine — GABA-A PAM. Very long effective t½ via active metabolites (desmethyldiazepam, oxazepam) — accumulation in elderly + chronic dosing. Muscle relaxant activity notable.

Half-Life (t½)

PO: 20h, IV: 20h

Dosing Guidelines

• PO: Typical 4.67mg (Range: 2 - 10 mg)
• IV: Typical 4.67mg (Range: 2 - 10 mg)
• IM: Typical 4.67mg (Range: 2 - 10 mg)

Target Organ Systems

• nervous