Ibuprofen

Category: pharmacological

Aliases: Advil, Motrin, Brufen

Pharmacological Mechanism

Reversible non-selective [[arachidonic_acid_cascade]] COX inhibitor. Reduces prostaglandin synthesis → analgesia, anti-inflammation, antipyresis. Reversibility means antiplatelet effect is dose-dependent + reversible (unlike [[aspirin]]'s irreversible acetylation).

Half-Life (t½)

PO: 1.9h, IV: 1.9h

Dosing Guidelines

• PO: Typical 400mg (Range: 200 - 800 mg)
• IV: Typical 400mg (Range: 200 - 800 mg)
• TD: Typical 400mg (Range: 200 - 800 mg)

Target Organ Systems

• immune-hematologic

Interactions

• Acetaminophen
• Apixaban
• Aspirin
• Dabigatran
• Rivaroxaban
• Warfarin