Human Biological Pathways & Signaling Registry

5-HT2A psychedelic signaling Acetylcholine synthesis + degradation Adaptogen HPA / cortisol stress modulation Adenosine receptor signaling Adrenergic receptor signaling Airway smooth-muscle tone Alzheimer disease Aminosugar metabolism AMPA + kainate glutamate receptor modulation AMPK energy sensor Androgenetic alopecia Anthelmintic + antiprotozoal targets Antimicrobial + cosmetic peptides Apoptosis (intrinsic + extrinsic)Aqueous humor / IOP regulation Arachidonic acid cascade Aromatase + androgen receptor Asthma Atherosclerosis plaque pathology Autonomic nervous system balance Autophagy (macroautophagy)Bacterial cell wall Bacterial DNA replication + folate synthesis Bacterial ribosome BDNF / TrkB neurotrophic signaling Bile acid Bile acid synthesis Biotin metabolism Bladder detrusor pharmacology Bone remodeling Bradykinin / kallikrein-kinin system Branched-chain amino acid (BCAA) metabolism Brown adipose thermogenesis Caffeine A1-adenosine cardiac ectopy Caffeine demethylation Calcineurin / NFAT T-cell activation Calcium / phosphate / PTH / vitamin D axis cAMP / PKA second-messenger signaling Carbonic anhydrase inhibitor paresthesia Cardiac action potential Carnitine shuttle Catecholamine synthesis CD4 T-helper differentiation Cell cycle Cellular senescence / SASP / senolytics cGAS-STING cytosolic DNA sensing → type I IFN CGRP axis Cholesterol absorption + reverse transport Cholesterol synthesis Choline / TMAO metabolism Circadian clock Coagulation cascade Coenzyme A synthesis Cognitive peptide axis Complement cascade Cough reflex arc + central antitussives Creatine / phosphocreatine energy buffer Creatine SLC6A8 intracellular osmotic loading CYP phase-1 drug metabolism overview Cytokine pathway biologic blockade DNA-damage cytotoxic chemotherapy Dopamine receptor signaling Endocannabinoid system Epidermal keratinization + melanogenesis Essential fatty acid conversion Estrogen phase-2 clearance Estrogen receptor (ERα / ERβ / GPER)Ethanol metabolism Fatty acid biosynthesis Fatty acid β-oxidation Ferroptosis Fibrinolysis Folate / one-carbon metabolism Fructose metabolism (fructolysis)Fungal ergosterol biosynthesis FXR / TGR5 bile-acid receptor signaling GABA-A receptor signaling GABA-B receptor signaling Gabapentinoid α2δ-1 Galactose metabolism Gastric acid secretion GI endocrine peptides GI motility + secretion GLP-1 central appetite + reward-cue dampening Glucocorticoid receptor (GR) signaling Gluconeogenesis Glutamate / glutamine cycle Glutamate receptor pharmacology Glutaminolysis → TCA anaplerosis Glutathione synthesis + redox cycle Glycerophospholipid metabolism Glycine / serine / threonine metabolism Glycogen synthesis + breakdown Glycolysis GnRH pulse generator Growth hormone / GHRH / GHS axis GSH / GSSG redox cycle HCV NS3/4A / NS5A / NS5B replication targets Hedgehog / Smoothened signaling Heme biosynthesis Heme degradation Hepcidin / ferroportin iron regulation HIF / oxygen-sensing axis Hippo / YAP-TAZ signaling Histamine receptor pharmacology Histamine synthesis + degradation HIV replication cycle blockade Hypothalamic-pituitary-adrenal axis Hypothalamic-pituitary-gonadal axis Hypothalamic-pituitary-thyroid axis IBD mucosal immunomodulation Immune checkpoint blockade Inositol phosphate / PI signaling Insulin signaling + glucose homeostasis Iron metabolism JAK-STAT signaling Ketone body metabolism + exogenous ketones Ketone body synthesis (ketogenesis)Klotho / FGF23 phosphate axis Kynurenine pathway LDL receptor + PCSK9 axis Lysine metabolism MAPK / ERK (RAS-RAF-MEK-ERK) cascade Mast cell stabilization + leukotriene axis Medicinal mushroom β-glucans Melanocortin receptor axis Melatonin MT1/MT2 dose-response + REM rebound Metabotropic glutamate receptors Methionine cycle Microbiome short-chain fatty acid signaling Mineral enzyme cofactor overview Mineralocorticoid receptor Minoxidil anagen-synchronization initial shed Mitochondrial-encoded peptide signaling Mitophagy Monoamine oxidase (MAO-A + MAO-B) metabolism mTOR signaling Muscarinic ACh receptor subtypes Mycobacterial cell envelope + RNA polymerase NAD+ / sirtuin / longevity axis NAFLD / MASH Necroptosis Neuroinflammation Neuromuscular junction blockade + reversal NF-κB signaling Niacin / NAD+ biosynthesis Niacin GPR109A cutaneous flush Nicotine metabolism Nicotinic ACh receptor pharmacology Nitric oxide synthesis NLRP3 inflammasome Notch signaling Nrf2 / Keap1 antioxidant response Nucleoside / nucleotide supplementation Omega-3 / omega-6 fatty acid elongation Opioid receptor signaling Orexin / wakefulness arousal axis Oxidative phosphorylation p53 / MDM2 DNA-damage response Parkinson disease PDE5 / NO-cGMP axis PDE5 inhibitor PDE6 retinal cross-inhibition Pentose phosphate pathway Phase-2 conjugation Phase-3 transport Phenylalanine metabolism PI3K / AKT signaling Platelet aggregation Polyol pathway Posterior pituitary PPAR α / γ / δ nuclear receptor signaling Progesterone receptor signaling Pulmonary arterial hypertension Purine catabolism Purine de novo synthesis Purinergic signaling Pyrimidine de novo synthesis + salvage Pyroptosis Pyruvate metabolism Reactive oxygen species (ROS) + oxidative stress Tyrosine kinase inhibition Renal tubular transport Renin-angiotensin-aldosterone axis Retinoic acid signaling Retinol / vitamin A metabolism Riboflavin renal overflow fluorescence Selective androgen receptor modulators (SARMs)Serine de novo synthesis → one-carbon pool Serotonin receptor pharmacology Skeletal muscle relaxants Skin antimicrobial + antiparasitic topicals Sphingolipid metabolism SSRI/SNRI discontinuation syndrome Steroid hormone biosynthesis Sunscreen + UV photoprotection Taurine synthesis + bile-acid conjugation TCA cycle Telomere maintenance + shelterin complex Tetrahydrobiopterin (BH4) cycle TGF-β signaling Thiamine metabolism Tissue repair peptides TLR (Toll-like receptor) innate signaling Topical anti-inflammatory skin Rx Transsulfuration → cysteine → glutathione Tricyclic + atypical antidepressants TRP channel sensory transduction Tryptophan → serotonin → melatonin Tryptophan metabolism Tyrosine metabolism (broader)Ubiquinone (CoQ10) biosynthesis Ubiquitin-proteasome degradation Unfolded protein response / ER stress Urea cycle Vasodilator pharmacology Viral polymerase inhibition Viral protease + neuraminidase Vitamin antioxidant axis Vitamin B12 (cobalamin) metabolism Vitamin B6 metabolism Vitamin D activation cascade Vitamin D receptor genomic signaling (VDR)Vitamin K cycle (γ-carboxylation)Volatile anesthetic action Voltage-gated calcium channels Voltage-gated sodium channels (Nav1.x)Warfarin metabolism Wnt / β-catenin canonical signaling Wound healing cascade β-Alanine MrgprD paresthesia