Category: immune_innate
Therapeutic mAbs + fusion proteins target inflammatory cytokines + their receptors in autoimmune + atopic disease. TNF-α: etanercept (soluble TNF-R2-Fc), adalimumab, golimumab, certolizumab-pegol (Fab-PEG), infliximab — RA / IBD / psoriasis / AS. IL-17: secukinumab + ixekizumab (anti-IL-17A) — psoriasis / PsA / AS. IL-12/23: ustekinumab (shared p40) — psoriasis / IBD. IL-23: guselkumab + risankizumab (selective p19) — psoriasis. IL-4/13: dupilumab (IL-4Rα) — atopic dermatitis + asthma + nasal polyps + EoE. IgE: omalizumab — allergic asthma + chronic spontaneous urticaria. CGRP migraine biologics covered separately (IMM-2). Bone biologics covered in IMM-4.