Category: biologic
Aliases: Xolair, anti-IgE mAb
Humanised IgG1κ mAb binding free IgE at the Cε3 domain (the FcεRI-binding site) → forms soluble trimeric/hexameric complexes that cannot engage FcεRI on mast cells/basophils. Downregulates FcεRI expression over weeks. Chronic suppression of allergic cascade.
SC: 624h