Riboflavin

Category: vitamin

Aliases: Vitamin B2

Pharmacological Mechanism

Precursor to flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) — redox cofactors for Complex I and II of the ETC, acyl-CoA dehydrogenases (β-oxidation), glutathione reductase, and xanthine oxidase. Light-sensitive; photolyses to lumichrome.

Half-Life (t½)

PO: 1.1h

Dosing Guidelines

• PO: Typical 1.17 mg (Range: 1.1–1.3 mg)

Target Organ Systems

• nervous
• musculoskeletal

Interactions

• Riboflavin-5'-Phosphate (synergistic): Same family — FMN is the activated form. No need to co-supplement; pick one.

Pathways It Modulates

• Riboflavin renal overflow fluorescence (substrate) — RFVT3 (intestinal) + glomerular filtration → urine
• Thiamine metabolism (cofactor) — vitamin B2 (FMN/FAD precursor)

Chemical Identifiers

• PubChem CID: 493570
• Formula: C17H20N4O6
• Molecular weight: 376.36 g/mol
• InChIKey: AUNGANRZJHBGPY-SCRDCRAPSA-N
• SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](CO)O)O)O

References

• PMID 8604671