Riboflavin-5'-Phosphate

Category: vitamin

Aliases: Riboflavin-5-phosphate, FMN, Flavin mononucleotide, Activated B2

Pharmacological Mechanism

FMN is one of the two active coenzyme forms of riboflavin (FMN, FAD). Directly incorporable into flavoenzymes without the RFK-mediated phosphorylation step required for riboflavin. Theoretical advantage in RFK polymorphisms; clinical advantage over plain riboflavin is small.

Half-Life (t½)

PO: 1.1h

Dosing Guidelines

• PO: Typical 23.3 mg (Range: 10–50 mg)

Target Organ Systems

• musculoskeletal

Interactions

• Riboflavin (synergistic): Same family — FMN is the activated form. No need to co-supplement; pick one.

Pathways It Modulates

• Thiamine metabolism (cofactor) — riboflavin-5-phosphate (active FMN)

Chemical Identifiers

• PubChem CID: 445395
• Formula: C17H23N4O9P
• Molecular weight: 230.11 g/mol
• InChIKey: YTNIXZGTHTVJBW-SCRDCRAPSA-N
• SMILES: CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)(O)O)O)O)O

References

• PMID 8604671