Manganese

Category: mineral

Aliases: Mn²⁺, Manganese bisglycinate, Manganese sulfate

Pharmacological Mechanism

Cofactor for manganese-SOD (mitochondrial antioxidant), arginase (urea cycle), pyruvate carboxylase (gluconeogenesis), and glutamine synthetase. Neurotoxic at chronic excess — accumulates in basal ganglia, producing a parkinsonism-like syndrome (manganism).

Dosing Guidelines

Target Organ Systems

Interactions