Glycine

Category: amino-acid

Pharmacological Mechanism

Inhibitory neurotransmitter; lowers core body temp via cutaneous vasodilation.

Half-Life (t½)

PO: 1h

Dosing Guidelines

• PO: Typical 3000 (Range: 1000–5000)

Target Organ Systems

• nervous
• cardiovascular
• integumentary

Interactions

• NAC (synergistic): Paired glutathione-synthesis precursor (cysteine + glycine → γGlu-Cys-Gly).

Pathways It Modulates

• Glycine / serine / threonine metabolism (substrate) — inter-convertible AA + GSH precursor + NMDA co-agonist
• Serine de novo synthesis → one-carbon pool (substrate) — glycine pool — major sink for one-carbon units; also GSH precursor
• Transsulfuration → cysteine → glutathione (substrate) — GSH second amino acid (often rate-limiting in elderly + chronic disease)

Chemical Identifiers

• PubChem CID: 750
• Formula: C2H5NO2
• Molecular weight: 75.07 g/mol
• InChIKey: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• SMILES: C(C(=O)O)N

References

• PMID 12450897