Erythromycin

Category: pharmacological

Pharmacological Mechanism

Macrolide antibiotic — binds bacterial 50S ribosome blocking translocation. Strong CYP3A4 inhibitor + motilin receptor agonist (gastric prokinesia). DDI source: rises statin levels, prolongs QT via co-administered CYP3A4 substrates.

Half-Life (t½)

PO: 1.5h, IV: 1.5h

Dosing Guidelines

• PO: Typical 500mg (Range: 250 - 500 mg)

Target Organ Systems

• cardiovascular
• digestive
• immune-hematologic

Interactions

• Simvastatin
• Midazolam
• Triazolam
• Sildenafil
• Alfentanil