Alfentanil

Category: pharmacological

Aliases: Alfenta

Pharmacological Mechanism

Synthetic μ-opioid agonist — phenylpiperidine class. ~⅕ fentanyl potency but faster onset (~1 min) and shorter duration. Used for short surgical procedures + rapid analgesia. CYP3A4 substrate (DDI with strong inhibitors).

Half-Life (t½)

IV: 1.5h

Dosing Guidelines

• IV: Typical 25 mcg (Range: 5–50 mcg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• Opioid receptor signaling (activator) — μ-opioid receptor

Chemical Identifiers

• PubChem CID: 51263
• Formula: C21H32N6O3
• Molecular weight: 416.52 g/mol
• InChIKey: IDBPHNDTYPBSNI-UHFFFAOYSA-N
• SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC

References

• PMID 17112806