EPA

Category: lipid

Aliases: Eicosapentaenoic acid, C20:5n3

Pharmacological Mechanism

C20:5 ω-3 polyunsaturated fatty acid. Substrate for COX/LOX enzymes generating series-3 (less inflammatory) prostaglandins + thromboxanes + series-5 leukotrienes. Direct modulator of inflammatory gene expression via PPAR-α, FFAR4. Cardiovascular + triglyceride-lowering effects.

Half-Life (t½)

PO: 18h

Dosing Guidelines

• PO: Typical 1000mg (Range: 500 - 4000 mg)

Target Organ Systems

• cardiovascular
• immune-hematologic