Clarithromycin

Category: pharmacological

Aliases: Biaxin

Pharmacological Mechanism

6-O-methyl erythromycin derivative — improved acid stability and tissue penetration. Strong CYP3A4 inhibitor (via 14-OH metabolite); first-line DDI perpetrator in clinical pharmacology. H. pylori eradication regimens.

Half-Life (t½)

PO: 5h, IV: 5h

Dosing Guidelines

• PO: Typical 500mg (Range: 250 - 500 mg)

Target Organ Systems

• digestive

Interactions

• Simvastatin
• Tacrolimus
• Midazolam
• Triazolam
• Atorvastatin
• Colchicine