Alanine

Category: amino-acid

Aliases: Ala, A, L-Alanine

Pharmacological Mechanism

Primary gluconeogenic substrate. The glucose-alanine cycle shuttles nitrogen from muscle BCAA catabolism to liver for urea synthesis and gluconeogenesis. Reversibly transaminated to pyruvate by ALT.

Dosing Guidelines

• PO: Typical 5 g (Range: 5–5 g)

Target Organ Systems

• digestive
• musculoskeletal

Pathways It Modulates

• Glycine / serine / threonine metabolism (substrate) — alanine pool

Chemical Identifiers

• PubChem CID: 5950
• Formula: C3H7NO2
• Molecular weight: 89.09 g/mol
• InChIKey: QNAYBMKLOCPYGJ-REOHCLBHSA-N
• SMILES: C[C@@H](C(=O)O)N

References

• PMID 10837313