Paroxetine

Category: pharmacological

Aliases: Paxil, Seroxat

Pharmacological Mechanism

Most potent SSRI at SERT + has weak anticholinergic + NE reuptake activity. Strong CYP2D6 inhibitor. Shortest t½ among SSRIs → most notorious discontinuation syndrome.

Half-Life (t½)

PO: 20h

Dosing Guidelines

• PO: Typical 26.7mg (Range: 10 - 60 mg)

Target Organ Systems

• nervous
• digestive

Interactions

• Tamoxifen
• Metoprolol
• Atomoxetine
• Desipramine
• Risperidone
• Aripiprazole
• Tramadol
• Carvedilol