Carvedilol

Category: pharmacological

Aliases: Coreg, Dilatrend

Pharmacological Mechanism

Combined β₁/β₂ + α₁ antagonist. α₁ blockade produces vasodilation offsetting β-blocker-induced afterload rise — advantageous in HFrEF. Evidence-base-first-line HF β-blocker (COPERNICUS trial 35% mortality reduction).

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 10.4mg (Range: 3.13 - 25 mg)

Target Organ Systems

• cardiovascular