Carvedilol

Category: pharmacological

Aliases: Coreg, Dilatrend

Pharmacological Mechanism

Combined β₁/β₂ + α₁ antagonist. α₁ blockade produces vasodilation offsetting β-blocker-induced afterload rise — advantageous in HFrEF. Evidence-base-first-line HF β-blocker (COPERNICUS trial 35% mortality reduction).

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 10.4 mg (Range: 3.13–25 mg)

Target Organ Systems

• cardiovascular

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — β1 + β2 + α1 (mixed)

Chemical Identifiers

• PubChem CID: 2585
• Formula: C24H26N2O4
• Molecular weight: 406.47 g/mol
• InChIKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O

References

• PMID 1982759
• PMID 32608144
• PMID 15655528