Tramadol

Category: pharmacological

Aliases: Ultram, ConZip

Pharmacological Mechanism

Weak µ-opioid agonist via CYP2D6-mediated conversion to O-desmethyltramadol (active metabolite with 200× µ-affinity vs parent). Parent compound is a serotonin + norepinephrine reuptake inhibitor — serotonergic load creates seizure + serotonin-syndrome risk. CYP2D6 polymorphism drives analgesia + respiratory depression variability.

Half-Life (t½)

PO: 5.5h, IV: 5.5h

Dosing Guidelines

• PO: Typical 66.7mg (Range: 50 - 100 mg)
• IV: Typical 66.7mg (Range: 50 - 100 mg)

Target Organ Systems

• nervous
• respiratory
• digestive