Desipramine

Category: pharmacological

Aliases: Norpramin

Pharmacological Mechanism

Secondary-amine TCA — active metabolite of imipramine. Strongest NE reuptake inhibition + lowest anticholinergic burden among TCAs. Used for depression + neuropathic pain when SSRIs fail.

Half-Life (t½)

PO: 21h

Dosing Guidelines

• PO: Typical 150mg (Range: 25 - 300 mg)

Target Organ Systems

• nervous