Aripiprazole

Category: pharmacological

Aliases: Abilify, Aristada

Pharmacological Mechanism

D2 + 5-HT1A partial agonist + 5-HT2A antagonist. Partial agonism acts as 'dopaminergic stabiliser' — reduces DA tone in mesolimbic hyperactivity, elevates it in mesocortical hypoactivity. Lower EPS + prolactin elevation than typical antipsychotics; metabolic side effects still present but less than olanzapine/quetiapine.

Half-Life (t½)

PO: 75h, IM: 75h

Dosing Guidelines

Target Organ Systems