Metoprolol

Category: pharmacological

Aliases: Lopressor (tartrate), Toprol XL (succinate)

Pharmacological Mechanism

Cardioselective β₁ blocker. Short-acting tartrate for acute BP/HR control; long-acting succinate for HFrEF (MERIT-HF trial). CYP2D6 substrate — major interaction source.

Half-Life (t½)

PO: 3.5h, IV: 3.5h

Dosing Guidelines

• PO: Typical 83.3mg (Range: 25 - 200 mg)
• IV: Typical 83.3mg (Range: 25 - 200 mg)

Target Organ Systems

• cardiovascular
• digestive