Metoprolol

Category: pharmacological

Aliases: Lopressor (tartrate), Toprol XL (succinate)

Pharmacological Mechanism

Cardioselective β₁ blocker. Short-acting tartrate for acute BP/HR control; long-acting succinate for HFrEF (MERIT-HF trial). CYP2D6 substrate — major interaction source.

Half-Life (t½)

PO: 3.5h, IV: 3.5h

Dosing Guidelines

• PO: Typical 83.3 mg (Range: 25–200 mg)
• IV: Typical 83.3 mg (Range: 25–200 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — β1-cardioselective
• Autonomic nervous system balance (inhibitor) — β1 (sympathetic arm — HR, contractility)

Chemical Identifiers

• PubChem CID: 4171
• Formula: C15H25NO3
• Molecular weight: 267.36 g/mol
• InChIKey: IUBSYMUCCVWXPE-UHFFFAOYSA-N
• SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOC)O

References

• PMID 1982759
• PMID 17420778
• PMID 10895074