Risperidone

Category: pharmacological

Aliases: Risperdal

Pharmacological Mechanism

Atypical antipsychotic — D2 + 5-HT2A receptor antagonist. CYP2D6 substrate; active 9-OH metabolite (paliperidone) drives much of the effect. Schizophrenia, bipolar, and autism-associated irritability.

Half-Life (t½)

PO: 20h, IM: 20h

Dosing Guidelines

• PO: Typical 2mg (Range: 0.5 - 6 mg)

Target Organ Systems

• nervous
• digestive