Category: alkaloid
Aliases: Raubasine, δ-Yohimbine, delta-Yohimbine, Tetrahydroserpentine
A corynanthe-type indole alkaloid present in yohimbe bark (Pausinystalia johimbe) that shares the pentacyclic indole core of yohimbine. Functional studies in pithed rats show it acts as a preferential α₁-adrenoceptor antagonist (PMID:3021076). Marketed elsewhere (as raubasine) as a cerebral vasodilator; quantitative human receptor pharmacology and clinical PK are not characterised. It is also a potent inhibitor of human CYP2D6 (Ki ≈ 3.3 nM; GtoPdb, PMID:8487254), a potential basis for pharmacokinetic interactions.