Nortriptyline

Category: pharmacological

Aliases: Pamelor

Pharmacological Mechanism

Secondary-amine TCA — active metabolite of amitriptyline. Stronger NE reuptake / weaker serotonergic + lower anticholinergic burden vs amitriptyline. Better-tolerated TCA for chronic pain, depression-with-pain, smoking cessation.

Half-Life (t½)

PO: 30h

Dosing Guidelines

• PO: Typical 75mg (Range: 25 - 150 mg)

Target Organ Systems

• nervous