Nebivolol

Category: pharmacological

Aliases: Bystolic

Pharmacological Mechanism

Third-generation β1-selective adrenergic blocker — also stimulates endothelial nitric oxide synthesis → vasodilation that other β-blockers lack. Lower fatigue + sexual side-effect profile. CYP2D6 substrate; poor metabolizers have ~10× higher AUC.

Half-Life (t½)

PO: 12h

Dosing Guidelines

• PO: Typical 5 mg (Range: 2.5–40 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — β1 + NO release

Chemical Identifiers

• PubChem CID: 71301
• Formula: C22H25F2NO4
• Molecular weight: 405.43 g/mol
• InChIKey: KOHIRBRYDXPAMZ-UHFFFAOYSA-N
• SMILES: C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O

References

• PMID 26914703
• PMID 2462161