Nebivolol

Category: pharmacological

Aliases: Bystolic

Pharmacological Mechanism

Third-generation β1-selective adrenergic blocker — also stimulates endothelial nitric oxide synthesis → vasodilation that other β-blockers lack. Lower fatigue + sexual side-effect profile. CYP2D6 substrate; poor metabolizers have ~10× higher AUC.

Half-Life (t½)

PO: 12h

Dosing Guidelines

• PO: Typical 5mg (Range: 2.5 - 40 mg)

Target Organ Systems

• cardiovascular
• digestive