International Union of Basic and Clinical Pharmacology (NC-IUPHAR) and the British Pharmacological Society (University of Edinburgh)
identifier format
Numeric Target ID and Ligand ID mapped to HGNC symbols and UniProt accessions
license
Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
introduced
2012
Core Principles & Analysis
Established in 2012 as a joint initiative of the IUPHAR Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR, founded 1987) and the British Pharmacological Society, GtoPdb superseded the earlier IUPHAR-DB and Guide to Receptors and Channels.
Subcommittees of domain pharmacologists curate authoritative target pages covering all human G-protein-coupled receptors, voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, transporters, and enzymes.
Unlike bulk literature aggregators, GtoPdb selects verified reference agonists, antagonists, allosteric modulators, and radioligands with consensus pKi, pKd, pIC50, and pEC50 values across human, mouse, and rat orthologues.