TB-500

Category: peptide

Aliases: Thymosin β4 fragment 17-23

Pharmacological Mechanism

Short 7-residue fragment containing the 'actin-binding' motif of thymosin β4. G-actin sequestration → cytoskeletal remodelling + cell migration → proposed mechanism for tendon / wound / vascular repair effects. Popular in performance-recovery circles; limited human data.

Dosing Guidelines

• SC: Typical 3 mg (Range: 2–5 mg)

Target Organ Systems

• musculoskeletal

Interactions

• BPC-157 (synergistic): Commonly paired for tendon / injury-recovery protocols; distinct mechanisms (VEGF vs actin-binding).
• Thymosin β4 (synergistic): TB-500 is the 7-aa fragment of the central active domain. Full-length Tβ4 has longer t½ and more biological activities.

Pathways It Modulates

• Tissue repair peptides (activator) — actin sequestration + tissue migration

Chemical Identifiers

• PubChem CID: 62707662
• Formula: C38H68N10O14
• Molecular weight: 889 g/mol
• InChIKey: ADKDNDYYIZUVCZ-ZQNQAVPYSA-N
• SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)C)O