BPC-157

Category: peptide

Aliases: Body Protection Compound-157, PL 14736, pentadecapeptide BPC 157

Pharmacological Mechanism

15-residue fragment of a gastric juice protein. Proposed mechanisms (rat/preclinical-dominant): VEGF upregulation, nitric-oxide pathway modulation, ECM / collagen-I remodelling during tendon and enterocyte repair. Oral route appears partially active despite peptide lability — mechanism disputed.

Half-Life (t½)

SC: 0.25h

Dosing Guidelines

• SC: Typical 300 mcg (Range: 200–500 mcg)
• PO: Typical 300 mcg (Range: 200–500 mcg)

Target Organ Systems

• musculoskeletal

Interactions

• TB-500 (synergistic): Commonly paired for tendon / injury-recovery protocols; distinct mechanisms (VEGF vs actin-binding).

Pathways It Modulates

• Tissue repair peptides (activator) — angiogenesis + VEGFR2 + NO (mechanism partial)

Chemical Identifiers

• PubChem CID: 9941957
• Formula: C62H98N16O22
• Molecular weight: 1419.5 g/mol
• InChIKey: HEEWEZGQMLZMFE-RKGINYAYSA-N
• SMILES: C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(=O)O)NC(=O)CN

References

• PMID 28035768