Magnesium Glycinate

Category: mineral

Aliases: magnesium bisglycinate

Pharmacological Mechanism

NMDA antagonism, calcium channel modulation, GABA-A potentiation.

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 300 (Range: 100–600)

Target Organ Systems

• nervous

Interactions

• Magnesium (synergistic): Same elemental mineral — glycinate is a preferred low-GI form.
• Magnesium L-threonate (synergistic): Often stacked: glycinate for systemic Mg and sleep onset, threonate for CNS penetration and memory.
• Magnesium Citrate (synergistic): Use glycinate instead if citrate's laxative effect is dose-limiting.

Notes

Glycinate form well-tolerated GI; preferred for sleep stack.

Pathways It Modulates

• Mineral enzyme cofactor overview (cofactor) — ATP-Mg complex (glycinate chelate)

Chemical Identifiers

• PubChem CID: 84645
• Formula: C4H8MgN2O4
• Molecular weight: 172.42 g/mol
• InChIKey: AACACXATQSKRQG-UHFFFAOYSA-L
• SMILES: C(C(=O)[O-])N.C(C(=O)[O-])N.[Mg+2]

References

• PMID 27910808
• PMID 7815675