Leukotrienes

Mediates inflammatory and allergic responses, derived from arachidonic acid through the lipoxygenase pathway.

Key Functions:

• Promote bronchoconstriction in asthma.
• Increase vascular permeability and leukocyte chemotaxis.
• Contribute to the pathogenesis of various inflammatory diseases.

Interacting Systems & Components:

• Eicosanoids (class of lipids they belong to)
• Prostaglandins (related inflammatory mediators)
• Lipoxygenases (enzymes that synthesize them)
• Immune System (key mediators of immune responses)
• Bronchi (cause constriction)