Voriconazole

Category: pharmacological

Aliases: Vfend

Pharmacological Mechanism

Second-gen triazole; extended-spectrum antifungal (Aspergillus, Fusarium, Scedosporium). Strong CYP2C19 + CYP2C9 + CYP3A4 inhibitor. CYP2C19 polymorphism drives extreme exposure variability — TDM strongly recommended. Visual disturbances (~30%) at therapeutic levels.

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 300 mg)

Target Organ Systems

• digestive
• immune-hematologic

Interactions

• Tacrolimus
• Cyclosporine
• Midazolam
• Alfentanil
• Omeprazole
• Sirolimus