UMP

Category: nucleotide

Aliases: Uridine-5'-monophosphate, Disodium uridylate

Pharmacological Mechanism

Dephosphorylated in the gut to uridine, which is absorbed via ENT1/2 — so UMP supplementation is effectively a uridine pro-drug. Once inside, re-phosphorylated to UMP → UDP → UTP, and on to the Kennedy pathway for phospholipid synthesis. Memory / cognitive research pairs UMP with DHA + choline.

Dosing Guidelines

• PO: Typical 267 mg (Range: 150–500 mg)

Target Organ Systems

• nervous

Interactions

• Uridine (synergistic): UMP dephosphorylates to uridine in the gut — same downstream effect.

Pathways It Modulates

• Pyrimidine de novo synthesis + salvage (substrate) — pyrimidine nucleotide; UMP→UDP→UTP+CTP

Chemical Identifiers

• PubChem CID: 6030
• Formula: C9H13N2O9P
• Molecular weight: 324.18 g/mol
• InChIKey: DJJCXFVJDGTHFX-XVFCMESISA-N
• SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O