Category: adaptogen
Aliases: Crocus sativus stigma extract, Affron
Stigma extract; crocin + safranal + picrocrocin are the named actives. Multiple meta-analyses report antidepressant effect comparable to fluoxetine 20 mg in mild-to-moderate depression. SSRI-like serotonin reuptake modulation suggested; mechanism not fully resolved.
PO: 8h