Crocin

Category: terpenoid

Pharmacological Mechanism

Glycosylated apocarotenoid (crocin-1 = trans-crocetin di(β-D-gentiobiosyl) ester). The dominant water-soluble pigment in Crocus sativus stigma. Antidepressant signal in clinical trials (typical dose 30 mg saffron extract standardized to ≥2% crocins). Mechanism via 5-HT + NMDA + BDNF modulation.

Half-Life (t½)

PO: 6.5h

Dosing Guidelines

• PO: Typical 6 mg (Range: 1–30 mg)

Target Organ Systems

• nervous

Chemical Identifiers

• PubChem CID: 5281233
• Formula: C44H64O24
• Molecular weight: 976.96 g/mol
• InChIKey: SEBIKDIMAPSUBY-RTJKDTQDSA-N
• SMILES: C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)/C)/C)/C=C/C=C(/C(=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)\C