Ritonavir

Category: pharmacological

Aliases: Norvir

Pharmacological Mechanism

HIV-1 protease inhibitor; modern use is as a PK booster (CYP3A4 inhibitor) for other PIs and Paxlovid. Most potent oral CYP3A4 inhibitor available. Major DDI source — extensive contraindication list (statins, ergots, sedatives, alpha-blockers).

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 100mg (Range: 100 - 600 mg)

Target Organ Systems

• cardiovascular
• digestive

Interactions

• Atorvastatin
• Simvastatin
• Tacrolimus
• Midazolam
• Sildenafil
• Alprazolam
• Fentanyl
• Amlodipine